The ovaroids are described in detail in a new paper published today in eLife. Through an agreement with Harvard’s Office of Technology Development (OTD), this technology has been licensed to Gameto, which is using it to develop therapeutics for diseases of the female reproductive system. This “ovaroid” model enables the study of human ovarian biology without the need to take tissue from patients, and could enable the development of new treatments for conditions like infertility, ovarian cancer, and more. Now, researchers at the Wyss Institute for Biologically Inspired Engineering at Harvard University, Harvard Medical School (HMS) and Duke University in collaboration with Gameto, a biotechnology company developing therapies to improve the female reproductive journey, have created a living, fully human ovarian organoid that supports egg cell maturation, develops follicles, and secretes sex hormones. Scientists have been working on creating in vitro models of human ovaries so that we can learn more about them and develop treatments for ovarian conditions, but most existing models use a combination of human and mouse cells, which do not faithfully replicate human ovary functions and take a long time to grow in the lab. ![]() Despite the fact that we all start out as an egg cell in one of our mother’s ovaries, these human reproductive organs are surprisingly under-studied.
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